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From northern Minnesota to its mouth at the Gulf of Mexico, the Mississippi River offers a uniquely American cruise experience. With more than 50 years’ experience and a fleet of 5 ships ranging from steamboat-style paddlewheelers to the newest modern luxury riverboats, American Cruise Lines is the leading operator of Mississippi River cruises.
Our 12 unique itineraries provide guests more ways to explore the Mississippi than any other cruise line, while the sophisticated comfort of our modern riverboats offers the largest staterooms, private balconies, and complimentary excursions at every port.
Receive Free Airfare & Savings up to $1,200* on select Lower Mississippi River Cruises. Expires September 30, 2024.
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MAP
Historic Mississippi River Cruise
New Orleans, LA to New Orleans, LA
Save up to $1,000
8 Days / 7 Nights
From
$3,535
Reserve Now View Cruise Details
MAP
Lower Mississippi River Cruise
Memphis, TN to New Orleans, LA
Free Airfare* Plus Save up to $1,200
9 Days / 8 Nights
From
$4,295
$3,795
Reserve Now View Cruise Details
MAP
Upper Mississippi River Cruise
St. Louis, MO to St. Paul, MN
Save up to $1,000
9 Days / 8 Nights
From
$4,610
Reserve Now View Cruise Details
MAP
Music Cities Cruise
Memphis, TN to Nashville, TN
Free Airfare* Plus Save up to $1,000
9 Days / 8 Nights
From
$4,295
Reserve Now View Cruise Details
MAP
Tennessee Rivers Cruise
Chattanooga, TN to Nashville, TN
Free Airfare* Plus Save up to $1,000
9 Days / 8 Nights
From
$4,295
Reserve Now View Cruise Details
MAP
Mississippi Explorer Cruise
New Orleans, LA to Memphis, TN
Free Airfare* Plus Save up to $1,200
12 Days / 11 Nights
From
$7,275
$6,675
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MAP
Ohio River Cruise
Louisville, KY to Pittsburgh, PA
Free Airfare* Plus Save up to $1,000
9 Days / 8 Nights
From
$4,530
$4,030
Reserve Now View Cruise Details
MAP
Great Smoky Mountains National Park
Knoxville, TN to Nashville, TN
12 Days / 11 Nights
From
$6,795
Reserve Now View Cruise Details
MAP
Complete Mississippi River Cruise
New Orleans, LA to St. Paul, MN
Free Airfare* Plus Save up to $1,500
23 Days / 22 Nights
From
$15,890
$15,140
Reserve Now View Cruise Details
MAP
Grand Heartland Cruise
St. Paul, MN to New Orleans, LA
Save up to $1,200
16 Days / 15 Nights
From
$10,440
Reserve Now View Cruise Details
MAP
Mississippi River Gateway Cruise
New Orleans, LA to Louisville, KY
Free Airfare* Plus Save up to $1,200
12 Days / 11 Nights
From
$6,245
$5,645
Reserve Now View Cruise Details
MAP
Grand Ohio River Cruise
Pittsburgh, PA to St. Louis, MO
Free Airfare* Plus Save up to $1,200
16 Days / 15 Nights
From
$7,685
$7,085
Reserve Now View Cruise Details
*Offer Valid Only on New Bookings on Select Dates
Trustpilot
Mississippi River Excursions
Embark on an unforgettable journey with American Cruise Lines as we navigate the vibrant waterways on one of our Mississippi River Cruises. Experience the unique charm and cultural richness of cities like New Orleans, Baton Rouge, and Memphis, each offering a glimpse into America's storied past and musical heritage.Learn more about how to plan your Mississippi River Cruise vacation with American Cruise Lines.
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America's Most Awarded Mississippi River Cruise Line
Our Mississippi River Fleet
American Melody
American Symphony
American Serenade
American Heritage
American Splendor
What Sets Us Apart
Made For You: A Personalized Mississippi River Cruise
Our Modern Riverboats are the newest ships on the Mississippi River. With a guest capacity of 180, our ships promise a more personalized experience than any other cruise line. Crew on American Cruise Lines can get to know you throughout your stay. We pay attention to you and your preferences to ensure your voyage is perfect for you. Our Paddlewheelers, with a classic Americana look, offer guests an authentic and nostalgic journey. Our onboard experts become a part of the experience as they travel with you and narrate your venture both on board and on shore. You’ll even be able to dine with your expert along the way.
Unique Excursions, Local Guides
From New Orleans, LA to St. Paul, MN, enjoy well-customized excursions, led by engaging local guides who live and work in these great port cities of America’s Heartland. Get a backstage pass to Elvis’ Graceland and the legendary Sun Studio in Memphis. Explore the boyhood town of Mark Twain in Hannibal and be treated to a live show at the Grand Old Opry in Nashville.
Onboard Experience
Get ready to jive where jazz, blues, and rock 'n' roll were born. Our amazing onboard musicians will keep you entertained with tunes that echo the river's soul. Feast on the best Cajun and Creole dishes and classic Memphis BBQ, all crafted by our top-notch chefs. Listen to our onboard experts bring the stories of the river to life at every port of call. Each evening, join us for a complimentary co*cktail hour, perfect for swapping stories with fellow travelers over a refreshing mint julep. Cheers to unforgettable moments.
All-Inclusive Cruising
No matter which ship you choose, you’ll be staying in the largest stateroom in the industry. With private balconies and numerous common areas, you’ll have the perfect spot to watch the lively banks of this historic river roll by. Everything you’ll need is included with your cruise fare. All food, drinks (including beer, wine, and spirits), gratuities, and featured excursions are at no additional cost to you. And, to make your cruise experience truly all-inclusive, select itineraries offer Free Airfare and premium Pre-Cruise Packages that include a hotel stay and transportation to the ship. So, go ahead, enjoy yourself and see this amazing river in a whole new way, without reaching for your wallet.
Spacious Accommodations
Whether on board a modern riverboat or newly refurbished paddlewheeler, American Cruise Lines is proud to offer the largest staterooms in the industry, with full-size bathrooms, and private balconies offering the perfect vantage point from which to admire the scenic rolling river views. Guests can also look forward to discovering spacious lounges and quiet nooks to gather with fellow travelers.
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